Author

D. Elnatan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

M. Sun· 3 shared Y. Liu· 3 shared D. A. Agard· 2 shared D. Agard· 2 shared A. G. Larson· 1 shared A. G. Myasnikov· 1 shared A. Murru· 1 shared A. Myasnikov· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

M. Sun

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states

Y. Liu, M. Sun, D. Elnatan, A. G. Larson, D. A. Agard

This study uses cryo-EM to reveal multiple tetrameric states of human TRAP1, showing dimer-dimer interactions and domain swapping contribute to tetramer stability.

bioRxiv · Nov 4, 2020 · PreprintBiophysics

Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates

Y. Liu, D. Elnatan, M. Sun, A. Myasnikov, D. Agard

The paper uses cryo-EM to reveal how TRAP1 interacts with SdhB folding intermediates, showing client binding induces structural changes in TRAP1 and provides insights into its role in mitochondrial function.

bioRxiv · Oct 6, 2020 · PreprintBiophysics

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

Y. Liu, M. Sun, A. G. Myasnikov, D. Elnatan, N. Delaeter, M. Nguyenquang, D. Agard

The paper determines cryo-EM structures of Hsp90:Aha1 complexes in multiple states to reveal a multistep activation mechanism where Aha1 accelerates ATP hydrolysis and induces conformational changes in Hsp90.

bioRxiv · Jun 30, 2020 · PreprintBiophysics

Stereo In-Line Holographic Digital Microscope

T. Zimmerman, N. Antipac, D. Elnatan, A. Murru, S. Biswas, V. P. Pastore, M. Bonani, L. Waller, J. Fung, G. Fenu, S. Bianco

This paper introduces a stereo in-line holographic digital microscope that enables 3D imaging and classification of plankton using a single laser and white LED, reducing computational load and providing interactive 3D visualization.

bioRxiv · Oct 2, 2019 · PreprintCell Biology

Modulation of mitochondrial Hsp90 (TRAP1) ATPase activity by calcium and magnesium

D. A. Agard, D. Elnatan

This study shows calcium can replace magnesium to support TRAP1 ATPase activity, leading to cooperative ATP hydrolysis and a mechanism for controlling TRAP1 function based on ATP and divalent cation concentrations.

bioRxiv · Apr 18, 2018Biochemistry