Author

M. Nguyenquang

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Biophysics· 1

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

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A. G. Myasnikov· 1 shared D. Agard· 1 shared D. Elnatan· 1 shared M. Sun· 1 shared N. Delaeter· 1 shared Y. Liu· 1 shared

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2020-2020 · peak 1/yr

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1 shared paperBiophysics

A. G. Myasnikov

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1 paper

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BiophysicsbioRxivPreprintJun 30, 2020

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

Y. Liu, M. Sun, A. G. Myasnikov…·D. Agard

The paper determines cryo-EM structures of Hsp90:Aha1 complexes in multiple states to reveal a multistep activation mechanism where Aha1 accelerates ATP hydrolysis and induces conformational changes in Hsp90.

DOI 10.1101/2020.06.30.180695

cryo-EMexperimental assay

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