M. Sun

Asymmetric binding of coactivator SRC1 to FXR-RXR and allosteric communication within the complex

This study reveals the asymmetric binding of SRC1 to FXR-RXR and the allosteric communication within the complex, providing a structural model for understanding FXR function and its disease implications.

Rapid radiation of a plant lineage sheds light on the assembly of dry valley biomes

This study investigates the rapid radiation of the Isodon lineage in southwest China's dry valleys, linking it to habitat and growth form shifts during the Pliocene.

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

Lytic bacteriophages interact with respiratory epithelial cells and induce the secretion of antiviral and proinflammatory cytokines

This study investigates how lytic bacteriophages interact with respiratory epithelial cells and their effects on cytokine secretion, highlighting the need to consider mammalian responses in phage therapy.

PbrSYP71 regulates pollen tube growth by maintaining uneven distribution of the ER in Pyrus

This study identifies PbrSYP71 as a pollen tube-specific syntaxin that maintains uneven ER distribution by tethering ER to F-actin, promoting pollen tube growth in pear.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

This study identifies SntB as a regulator of growth, development, and aflatoxin biosynthesis in Aspergillus flavus by modulating antioxidant pathways and gene expression.

Biological characteristics and metabolic phenotypes of different anastomosis groups of Rhizoctonia solani strains

This study compares the biological characteristics and metabolic phenotypes of four Rhizoctonia solani anastomosis groups from tobacco, revealing differences in growth, sclerotia formation, pathogenicity, and substrate utilization.

High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation

This paper introduces LFMNR, a method for high-fidelity 3D reconstruction of biological dynamics using physics-informed neural representations and meta-learning, achieving improved resolution and speed.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

ATR promotes mTORC1 activity via de novo cholesterol synthesis

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Defense mechanism of a bacterial retron supramolecular assembly

The paper identifies a phage-encoded DNA methyltransferase as a trigger for the Ec86 retron system and describes its supramolecular assembly and defense mechanism.

Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4+ and CD8+ T Cells and Protects Against Recurrent Genital Herpes

This study shows that a prime/pull vaccine using HSV-2 RR2 protein and CXCL11 chemokine boosts CD4+ and CD8+ T cells in DRG and VM tissues, reducing recurrent genital herpes severity and frequency.

Multivalent Exosome based protein vaccine: a "mix and match" approach to epidemic viruses' challenges.

This study develops a multivalent exosome-based vaccine platform that effectively induces strong immune responses against multiple viruses using minimal protein and no adjuvant.

A Multi-Epitope/CXCL11 Prime/Pull Coronavirus Mucosal Vaccine Boosts the Frequency and the Function of Lung-Resident CD4+ and CD8+ Memory T Cells and Protects Against COVID-19-like Symptoms and Death Caused by SARS-CoV-2 infection

Enhancing anti-gastrointestinal cancer activities of CLDN18.2 CAR-T armored with novel synthetic NKG2D receptors Containing DAP10 and DAP12 signaling domains.

This paper develops a CAR-T therapy for gastrointestinal cancers by combining CLDN18.2 targeting with synthetic NKG2D receptors containing DAP10 and DAP12 domains, improving efficacy against heterogeneous tumors.

Enriched zones of embedded ribonucleotides are associated with DNA replication and coding sequences in the human mitochondrial genome

The paper identifies rNMP-enriched zones in human mtDNA linked to replication and coding sequences using ribose-seq across six cell types.

The Potential of Low Press and Hypoxia Environment in Assisting Pan-cancer Treatment

This study constructs a pan-cancer prognosis risk model using ADME genes under low press and hypoxia conditions, finding lower risk scores correlate with better survival in 25 cancer types.

Nanograms of SARS-CoV-2 Spike Protein Delivered by Exosomes Induce Potent Neutralization of Both Delta and Omicron Variants.

This study demonstrates that exosomes delivering nanogram amounts of SARS-CoV-2 Spike protein induce potent neutralization against Delta and Omicron variants and enhance T cell responses.

NuSAP participates in metaphase spindle length control in mammalians

This study identifies NuSAP's role in regulating metaphase spindle length by controlling microtubule flux and Kif2A localization during mitosis.

A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.

Exosome based multivalent vaccine: achieving potent immunization, broadened reactivity, and strong T cell responses with nanograms of proteins

This paper develops a multivalent exosome-based vaccine using nanogram doses of SARS-CoV-2 proteins without adjuvant, showing strong immune responses and cross-reactivity against variants.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

Arabidopsis ORP2A positively regulates glucose signaling by interacting with AtRGS1 and promoting AtRGS1 degradation

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

This study identifies neural vulnerabilities in glioblastoma by analyzing patient samples and model systems, revealing drug targets and pathways that can be exploited for treatment.

Pantothenate Kinase 4 Governs Lens Epithelial Fibrosis by Negatively Regulating PKM2 Related Glycolysis

This study identifies PANK4 as a regulator of lens epithelial fibrosis through its control of PKM2-related glycolysis and EMT.

TLR4/NF-κB Signaling Contributes to the Inflammation in Ovary and Inguinal Fats of Polycystic Ovary Syndrome

This study shows that TLR4/NF-κB signaling increases inflammation in ovarian and inguinal fat tissues of PCOS rats, worsening metabolic and reproductive symptoms.