Cell BiologybioRxivPreprint
B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening mediated by pioneering factors
D. F. Kaemena, M. Yoshihara, J. Ashmore…·K. Kaji
This study identifies ZFP266 as a reprogramming roadblock gene that suppresses chromatin opening by binding SINEs near pioneer factor binding sites, and shows that replacing its KRAB domain with a co-activator domain enhances reprogramming.