Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution
D. K. H. Chan, A. Mandal, Y. Zhou, S. D. Collins, R. Owen, J. Bundred, H. Fuchs, S. James, I. Vendrell, S. Flannery, D. Fawkner-Corbett, J. Househam, T. A. Graham, R. Fischer, A. Simmons, , S. J. A. Buczacki
This study shows that the order of FBXW7 and APC mutations affects colorectal cancer initiation, with FBXW7 mutations before APC preventing cancer-like features.
bioRxiv · Aug 25, 2023 · PreprintCancer Biology