H. Fuchs

Early body weight gain in TALLYHO/JngJ mice predicts adult diabetic phenotype, mimicking childhood obesity

The paper identifies weaning body weight as a key predictor of adult diabetes in TALLYHO/JngJ mice, highlighting its relevance to childhood obesity research.

Comparative phenotyping of mice reveals canonical and noncanonical physiological functions of TRα and TRβ

This study compares TRα and TRβ knockout mice with DNA-binding-deficient mutants to show noncanonical TR signaling contributes to physiological functions beyond canonical genomic pathways.

Canonical and noncanonical contribution of thyroid hormone receptor isoforms alpha and beta to cardiac hypertrophy and heart rate in male mice

This study shows that thyroid hormone-induced cardiac hypertrophy relies on noncanonical TR action, while heart rate regulation depends on canonical TR action, with TRβ compensating for TR absence.

TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity

This study shows TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity, linking it to mechanotransduction and breast cancer initiation.

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

This study shows that the order of FBXW7 and APC mutations affects colorectal cancer initiation, with FBXW7 mutations before APC preventing cancer-like features.

New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance

This paper describes a new mouse model with a KIT mutation that develops late-onset mammary tumors with high penetrance and lung metastasis.

Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J Mice

This study uses large-scale phenotyping in mice to show that longevity regulators affect age-sensitive phenotypes before detectable aging begins, rather than slowing aging rates.

Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria

This study examines a mouse model of methylmalonic aciduria, finding reduced energy expenditure, altered metabolism, and metabolic inflexibility.

Dietary intervention improves health metrics and life expectancy of the genetically obese DU6 (Titan) mouse

The study characterizes the Titan mouse as a model for metabolically unhealthy obesity and shows that dietary intervention improves its health and extends lifespan.

Parp3 promotes long-range end-joining in murine cells

This study shows Parp3 promotes chromosomal rearrangements in murine cells, contrasting with Parp1's suppressive role in DNA double-strand break processing.