S. James

Parallel evolution of plant alkaloid biosynthesis from bacterial-like decarboxylases

This study identifies OLADOs, a new class of eukaryotic decarboxylases involved in alkaloid biosynthesis, showing their parallel evolution from bacterial-like enzymes.

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

This study shows that the order of FBXW7 and APC mutations affects colorectal cancer initiation, with FBXW7 mutations before APC preventing cancer-like features.

LINC00261 expression reduces mutation accumulation while conferring resistance to cisplatin and altering the tumor-immune microenvironment in lung adenocarcinoma

This study identifies LINC00261 as a gene that reduces mutation accumulation, confers cisplatin resistance, and alters the tumor-immune microenvironment in lung adenocarcinoma.

UVB modifies skin immune-stroma cross-talk and promotes effector T cell recruitment during cryptic Leishmania donovani infection

This study uses scRNA-seq and spatial transcriptomics to show UVB exposure alters immune-stromal interactions and T cell recruitment during cryptic Leishmania donovani infection.

Endosomal cargo recycling mediated by Gpa1 and Phosphatidylinositol-3-Kinase is inhibited by glucose starvation

The paper shows glucose starvation inhibits endosomal cargo recycling by altering PI3K activity through Gpa1 and Gpa2 interactions.

Multiple targets of balancing selection in Leishmania donovani complex parasites

This study identifies five genetically distinct populations in Leishmania donovani complex parasites and finds balancing selection signals not shared between populations, highlighting 19 candidate genes.

Identification of uterine pacemaker regions at the myometrial-placental interface

The paper identifies uterine pacemaker regions at the myometrial-placental interface in late pregnant rats using multi-electrode recordings and 3D reconstructions, showing they arise from modified smooth muscle bundles.