Structural dynamics determine voltage and pH gating in human voltage-gated proton channel
S. Han, S. Peng, J. Vance, K. Tran, N. Do, D. Gates, N. Bui, Z. Gui, S. Wang
This study uses smFRET to examine real-time conformational dynamics of the hHv1 voltage sensor under different voltage and pH conditions, revealing that gating is determined by conformational distributions rather than transitions between resting and activated states.
bioRxiv · Aug 25, 2021Biophysics