K. Tran

Molecular Basis for RNA Cytidine Acetylation by NAT10

This study determines the cryo-EM structure of NAT10 bound to a cytidine-CoA probe, revealing its mechanism for RNA N4-cytidine acetylation and its role in cellular processes.

Chemoproteomics identifies proteoform-selective caspase-2 inhibitors

The paper identifies proteoform-selective caspase-2 inhibitors using chemoproteomics, revealing a unique non-catalytic cysteine and validating their selectivity and activity.

Apelin improves angiogenesis and blood flow reperfusion following lower limb ischemia in diabetic mice

This study shows that Pyr-apelin-13 improves blood flow and angiogenesis in diabetic mice with limb ischemia, overcoming diabetes-induced resistance to VEGF.

An S1 subunit vaccine and combination adjuvant (COVAC-1) elicits robust protection against SARS-CoV-2 challenge in African green monkeys

COVAC-1, an S1 subunit vaccine with adjuvant, protects African green monkeys from SARS-CoV-2 challenge by reducing viral load and pathology in the respiratory tract.

SBML to bond graphs: from conversion to composition

The paper presents a framework to convert SBML models into bond graphs to ensure physical plausibility and thermodynamic consistency in biochemical models.

A semantics, energy-based approach to automate biomodel composition

The paper proposes an automated method to compose biosimulation models using semantic annotations and bond graphs, demonstrating it by integrating Ras-MAPK and EGFR models.

Structural dynamics determine voltage and pH gating in human voltage-gated proton channel

This study uses smFRET to examine real-time conformational dynamics of the hHv1 voltage sensor under different voltage and pH conditions, revealing that gating is determined by conformational distributions rather than transitions between resting and activated states.

Structurally related but genetically unrelated antibody lineages converge on an immunodominantHIV-1 Env neutralizing determinant following trimer immunization

The paper analyzes monoclonal antibodies from vaccinated non-human primates to identify a conserved immunodominant epitope in HIV-1 Env and how different lineages target it for potent neutralization.

Hierarchical semantic composition of biosimulation models using bond graphs

This paper introduces a method to compose biosimulation models using bond graphs and semantic annotations, demonstrating it on a human arterial circulation model to improve modularity and physical consistency.

Immunogenicity of novel mRNA COVID-19 vaccine MRT5500 in mice and non-human primates

This study evaluates the immunogenicity of the mRNA vaccine MRT5500 in mice and non-human primates, showing it elicits neutralizing antibodies and TH1-biased responses.

CpG-creating Mutations are Costly in Many Human Viruses

The paper examines the cost of CpG-creating mutations in various human viruses using existing genomic data and finds they are generally costly.