Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes
A. Knyazeva, S. Li, D. Corkery, K. Shankar, L. Herzog, X. Zhang, B. Singh, G. Niggemeyer, D. Grill, J. Gilthorpe, M. Gaetani, L.-A. Carlson, H. Waldmann, Y. Wu
This study inhibits the IST1-CHMP1B interaction in ESCRT-III, impairing endosomal recycling and inducing unconventional LC3 lipidation at stalled endosomes.
bioRxiv · Aug 28, 2023Cell Biology