L.-A. Carlson

Giardia intestinalis deoxyadenosine kinase has a unique tetrameric structure that enables high substrate affinity and makes the parasite sensitive to deoxyadenosine analogues

This paper characterizes Giardia intestinalis deoxyadenosine kinase, showing it forms a tetramer with high substrate affinity and sensitivity to deoxyadenosine analogues, making it a potential drug target.

In vitro reconstitution reveals membrane clustering and RNA recruitment by the enteroviral AAA+ ATPase 2C

This study reconstitutes the membrane clustering and RNA recruitment functions of the enteroviral 2C protein in vitro, revealing its roles in viral replication and challenging its helicase function.

Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

This study inhibits the IST1-CHMP1B interaction in ESCRT-III, impairing endosomal recycling and inducing unconventional LC3 lipidation at stalled endosomes.

Structural basis for lipid transfer by the ATG2A-ATG9A complex

This study determines the cryo-EM structures of ATG2A and ATG2A-ATG9A complexes, revealing their roles in lipid transfer during autophagosome formation.

Ribosome clustering and surface layer reorganization in the microsporidian host-invasion apparatus.

The paper uses microscopy and cryo-electron tomography to study the structural changes in microsporidian polar tubes during host invasion and identifies ribosome clustering in the cargo-filled state.

The organization of double-stranded RNA in the chikungunya virus replication organelle

This study examines the organization of double-stranded RNA in chikungunya virus spherules using cryo-electron tomograms, revealing structural features of the replication intermediate.

Architecture of the chikungunya virus replication organelle

This study uses cryo-electron tomography to reveal the architecture of CHIKV spherules and presents a mathematical model explaining their membrane remodeling.

Type I interferon shapes brain distribution and tropism of tick-borne flavivirus

The paper uses multimodal imaging and single nuclei RNA-sequencing to study how type I interferon affects viral tropism in the brain during flavivirus infection in mice.

Clinically observed deletions in SARS-CoV-2 Nsp1 affect protein stability and its ability to inhibit translation

The paper investigates how deletions in SARS-CoV-2 Nsp1 affect protein stability and translation inhibition, finding that certain deletions reduce translation inhibition while others impact interferon response.

Membrane-assisted assembly and selective autophagy of enteroviruses

This study uses cryo-electron tomography to show poliovirus assembles on replication membranes and uses autophagy for release, with selectivity for RNA-loaded virions.

The structure of enteric human adenovirus 41 - a leading cause of diarrhoea in children

This study determines the structure of enteric HAdV-F41 using cryo-EM, revealing structural differences from non-enteric HAdVs that explain its tissue tropism and pathogenicity.

ATP-dependent force generation and membrane scission by ESCRT-III and Vps4

ESCRT-III and Vps4 were reconstituted to generate ATP-dependent forces for membrane scission, confirming their role in membrane cutting.