Author

D. Guerrelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 5 Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Organism:rat· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

N. G. Posnack· 5 shared M. Reilly· 4 shared L. Swift· 3 shared M. Ramadan· 3 shared C. Mulvany· 2 shared J. Pressman· 2 shared N. Posnack· 2 shared R. Jaimes· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersPharmacology & Toxicology

N. G. Posnack

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Author profile →

7 papers

Recent·Most cited

Connecting Transcriptomics with Computational Modeling to Reveal Developmental Adaptations in the Human Pediatric Myocardium

S. Salameh, D. Guerrelli, J. A. Miller, M. Desai, N. Moise, C. Yerebakan, A. Bruce, P. Sinha, Y. d'Udekem, S. H. Weinberg, N. G. Posnack

This study analyzes age-dependent gene expression and electrophysiological changes in pediatric patients with congenital heart disease using computational modeling.

bioRxiv · Apr 19, 2024 · PreprintCell Biology

hiPSC-CM Electrophysiology: Impact of Temporal Changes and Study Parameters on Experimental Reproducibility

D. Guerrelli, J. Pressman, N. Posnack

This study examines how temporal changes and experimental parameters affect the electrophysiology of hiPSC-CMs, highlighting variability in beating rate, field potential duration, and drug responsiveness.

bioRxiv · Oct 2, 2023Physiology

Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexylphthalate (DEHP)

L. M. Swift, A. Roberts, J. Pressman, D. Guerrelli, S. Allen, K. Haq, J. Reisz, A. D'Alessandro, N. G. Posnack

This study shows DEHP exposure impairs cardiac function in rats, with dose- and time-dependent effects on conduction and rhythm.

bioRxiv · May 22, 2023 · PreprintPharmacology & Toxicology

Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

T. Prudencio, L. Swift, D. Guerrelli, B. Cooper, M. Reilly, N. Ciccarrelli, J. Sheng, R. Jaimes, N. G. Posnack

This study compares the effects of bisphenol analogues on cardiac electrophysiology, finding BPA and BPF inhibit ion channels more than BPS.

Toxicological Sciences · Jul 8, 2021Peer-reviewedPharmacology & Toxicology

Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease

J. Romanowicz, Z. Dhari, D. Guerrelli, C. Mulvany, M. Reilly, L. Swift, N. Vasandani, M. Ramadan, N. Ishibashi, N. Posnack

This study examines the effects of chronic perinatal hypoxia on cardiac development in a mouse model of cyanotic congenital heart disease, finding persistent electrophysiological and functional impairments.

bioRxiv · May 28, 2020Physiology

Potential consequences of the red blood cell storage lesion on cardiac electrophysiology

M. Reilly, C. Bruno, T. Prudencio, N. Ciccarelli, D. Guerrelli, R. Nair, M. Ramadan, N. Luban, N. G. Posnack

This study shows that older red blood cell units affect cardiac electrophysiology, likely due to biochemical changes, including hyperkalemia, and highlights risks for certain patient groups.

bioRxiv · May 22, 2020Physiology

Age-dependent changes in electrophysiology and calcium handling: implications for pediatric cardiac research

L. Swift, M. Burke, D. Guerrelli, M. Ramadan, M. Reilly, D. McCullough, A. Chaluvadi, C. Mulvany, R. Jaimes, N. G. Posnack

This study examines age-related changes in cardiac electrophysiology and calcium handling in rats, finding slowed conduction, prolonged action potentials, and altered gene expression in immature hearts.

bioRxiv · Jun 3, 2019Physiology