A. Roberts

Synthesis of ionizable lipopolymers using split-Ugi reaction for pulmonary delivery of various size RNAs and gene editing

The paper develops a method to deliver various RNA therapeutics, including mRNA and CRISPR-Cas9, to the lung using lipopolymer-lipid hybrid nanoparticles, showing improved efficacy and reduced toxicity.

The Myc-Like Mlx Network Impacts Aging and Metabolism

This study shows that inactivating the Mlx network in mice accelerates aging-related phenotypes and increases cancer risk, similar to Myc inactivation, but with different lifespan outcomes.

Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexylphthalate (DEHP)

This study shows DEHP exposure impairs cardiac function in rats, with dose- and time-dependent effects on conduction and rhythm.

KairoSight-3.0: Validated Optical Mapping Software to Characterize Cardiac Electrophysiology, Excitation-Contraction Coupling, and Alternans

KairoSight-3.0 is a software package for semi-automated analysis of cardiac optical mapping data, providing accurate measurements of electrophysiology, calcium transients, and excitation-contraction coupling.

Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide Myc Inactivation

This study investigates the effects of near-complete Myc inactivation in mice, finding premature aging features but reduced cancer incidence and linking Myc dysregulation to aging and cancer.

Regulators of male and female sexual development critical for transmission of a malaria parasite

The paper identifies ten genes critical for male and female sexual development in Plasmodium berghei and reveals a regulatory cascade governing gametogenesis.

Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasis

This study shows that loss of intra-islet glucagon receptor signaling impairs glucose tolerance and insulin pulsatility in mice, suggesting glucagonergic agents could restore insulin pulsatility in T2D.

Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia

This study investigates the interaction between the Myc and Mlx networks in liver regeneration and tumorigenesis, finding that the Mlx network plays a critical role in maintaining homeostasis and suppressing tumor formation.

Molecular mechanism of a parasite kinesin motor and implications for its inhibition

This study characterizes the molecular mechanism of Plasmodium falciparum kinesin-5 (PfK5) and identifies structural features that could enable selective inhibition of this parasite's motor.

eCovSens-Ultrasensitive Novel In-House Built Printed Circuit Board Based Electrochemical Device for Rapid Detection of nCovid-19 antigen, a spike protein domain 1 of SARS-CoV-2

This paper develops an in-house biosensor (eCovSens) for rapid detection of SARS-CoV-2 spike antigen in saliva, showing comparable sensitivity to a commercial potentiostat.

A Novel Model of Pancreatic Cancer Dormancy Reveals Mechanistic Insights and a Dormancy Gene Signature with Human Relevance

This study introduces a novel pancreatic cancer dormancy model, identifies a dormancy gene signature, and reveals mechanisms including chromatin remodeling and CCL5 as a novel marker.

Isolation of an antimicrobial resistant, biofilm forming, Klebsiella grimontii isolate from a re-usable water bottle.

The paper isolates a Klebsiella grimontii strain from a re-usable water bottle, identifies its antimicrobial resistance and biofilm-forming capabilities, and highlights hygiene concerns for reusable bottles.

Social bonding, gestural complexity and displacement behaviour of wild chimpanzee

This study examines how gestural communication in wild chimpanzees affects social affiliation, finding that affiliative gestures predict social bonding while contexts vary in their association with gesture complexity and displacement behavior.

Identification of a Type IV CRISPR-Cas system located exclusively on IncHI1B/ IncFIB plasmids in Enterobacteriaceae

The paper identifies a novel Type IV-B CRISPR-Cas system on IncHI1B/IncFIB plasmids in Enterobacteriaceae, showing it is active and associated with mobile genetic elements.

Predicting division planes of three-dimensional cells by soap-film minimization

The paper develops a mathematical model to predict cell division planes in plants and animals by simulating soap-film minima, showing it matches observed division sites and avoids unfavorable junctions.

Intentional gestures predict complex sociality in wild chimpanzee

The paper examines how intentional gestures in wild chimpanzees correlate with social complexity, finding that persistent gestures are linked to longer proximity and central social network positions.