M. Desai

Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine

This study compares SUD-like phenotypes in rats self-administering MDPV or cocaine under different access conditions, finding MDPV induces more severe phenotypes than cocaine under short-access.

Visible light optical coherence tomography angiography (vis-OCTA) and local microvascular retinal oximetry in human retina

This study introduces a visible light OCTA system for human retinal imaging, achieving high-speed acquisition and microvascular oximetry with sub-100 μm vessel resolution.

Target-responsive vasoactive probes for ultrasensitive molecular imaging

This paper develops target-responsive imaging probes that enable ultrasensitive detection of molecules in deep tissue using hemodynamic imaging in rat brains.

A role of cellular translation regulation associated with toxic Huntingtin protein

This study shows that pathogenic Huntingtin protein sequesters the translation regulator Orb2, leading to protein synthesis deficits and lethality, suggesting translation dysfunction as a contributor to Huntington's disease.

Combining amoxicillin and relebactam provides a new therapeutic option for Mycobacterium abscessus infection

This paper shows that combining amoxicillin and relebactam synergistically inhibits Mycobacterium abscessus through non-competitive inhibition of its beta-lactamase, offering a new therapeutic option for infections.

Early detection of retinal alteration by visible and near-infrared optical coherence tomography (vnOCT) in a dexamethasone-induced ocular hypertension mouse model

This study uses vnOCT to detect early retinal changes in a dexamethasone-induced ocular hypertension mouse model, finding that VN ratio and A-V sO2 correlate with RGC loss independent of IOP.

A role for GrgA in regulation of σ28-dependent transcription in the obligate intracellular bacterial pathogen Chlamydia trachomatis

This study shows GrgA activates both σ66 and σ28-dependent transcription in Chlamydia trachomatis by interacting with their non-conserved regions.