BiochemistrybioRxiv
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer's R47H mutant does the opposite
A. Vilalta, Y. Zhou, J. Sevalle…·G. C. Brown
The paper shows wild-type sTREM2 inhibits Aβ aggregation and neurotoxicity, while the R47H variant promotes Aβ aggregation and neurotoxicity.
DOI 10.1016/j.jbc.2021.100631