BioengineeringbioRxiv
Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy
D. ZHU, D. H. Brookes, A. Busia…·D. V. Schaffer
This paper develops a machine learning method to design more effective AAV libraries with better packaging capabilities and diversity, achieving higher success rates in gene therapy applications.
DOI 10.1126/sciadv.adj3786