D. Shin

Development of covalent probes to capture Legionella pneumophila effector enzymes

The paper develops covalent probes to target Legionella pneumophila effector enzymes, demonstrating their effectiveness in capturing DupA through in vitro testing and structural analysis.

Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and the clinical high-risk state for psychosis

The paper identifies cellular and neurochemical signatures associated with cerebral blood flow alterations in schizophrenia and clinical high-risk states using combined neuroimaging and transcriptomic data.

Serine ubiquitination of p62 regulates Nrf2 dependent redox homeostasis

This study shows that serine ubiquitination of p62 by Legionella pneumophila SidE effectors inhibits Nrf2 signaling, altering redox homeostasis and host metabolism during infection.

Altered methionine metabolism impacts phenylpropanoid production and plant development in Arabidopsis thaliana

This study shows that aliphatic aldoximes repress phenylpropanoid production and that altered methionine metabolism affects plant growth and development in Arabidopsis.

VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

Label-free histological analysis of retrieved thrombi in acute ischemic stroke using optical diffraction tomography and deep learning

This study uses optical diffraction tomography and deep learning to automate thrombus composition analysis in acute ischemic stroke, achieving high accuracy and reducing labor.

Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases

This study reveals the structural features and mechanism of Legionella OTU deubiquitinases, showing their unique extended helical lobe and cooperative chain cleavage activity.

Potentiating the cross-reactive IFN-γ T cell and polyfunctional T cell responses by heterologous GX-19N DNA booster in mice primed with either a COVID-19 mRNA vaccine or inactivated vaccine

This study evaluates the effectiveness of a DNA booster vaccine in enhancing immune responses in mice previously vaccinated with either an mRNA or inactivated SARS-CoV-2 vaccine.

A new protocol for speed vernalisation of winter cereals

This paper introduces a new vernalisation protocol that significantly reduces generation time for winter cereals by combining extended photoperiod and low-temperature exposure with speed breeding conditions.

Marked enhancement of neutralizing antibody and IFN-γ T-cell responses by GX-19N DNA booster in mice primed with inactivated vaccine

This study shows that a heterologous prime-boost regimen using inactivated SARS-CoV-2 vaccine and GX-19N DNA vaccine enhances neutralizing antibody and IFN-γ T-cell responses against SARS-CoV-2 and its variants in mice.

Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy

This paper develops a machine learning method to design more effective AAV libraries with better packaging capabilities and diversity, achieving higher success rates in gene therapy applications.

β-Catenin-NFκB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.

Focused Ultrasound Modulation of Hepatic Neural Plexus Restores Glucose Homeostasis in Diabetes

The paper demonstrates that focused ultrasound activation of the hepatic neural plexus restores glucose homeostasis in diabetes models across multiple species.

Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir

The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.

Collective nuclear behavior shapes bilateral nuclear symmetry for subsequent left-right asymmetric morphogenesis in Drosophila

The paper shows that collective nuclear behavior and Wnt4 signaling guide symmetric nuclear positioning, which is essential for subsequent left-right asymmetric development in Drosophila.

Sensitivity of radio-photoluminescence glass dosimeters to accumulated doses

This study examines how accumulated doses affect radio-photoluminescence glass dosimeters (RPLGDs) under different photon energies and irradiation conditions.

Revealing architectural order with quantitative label-free imaging and deep learning

This paper combines label-free imaging with deep learning to analyze biological structures, showing it can predict 3D fluorescent features in tissues.

Differential Profiles of Soluble and Cellular Toll-like Receptors (TLRs) 2 and 4 in Chronic Periodontitis.

This study examines salivary soluble TLR-2/4 and epithelial cell-associated TLR-2/4 mRNA levels in periodontitis and gingivitis patients to assess their potential as diagnostic markers.