Author

D. Heintzman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

A. Sugiura· 3 shared C. Chi· 3 shared J. Rathmell· 3 shared C. A. Lyssiotis· 2 shared H. Hong· 2 shared K. Voss· 2 shared X. Ye· 2 shared A. C. Young· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

A. Sugiura

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Author profile →

3 papers

Recent·Most cited

Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4+ T Cell Function and Oxidative Metabolism

K. K. Steiner, A. C. Young, A. R. Patterson, E. Q. Jennings, C. Chi, Z. Hatem, D. Heintzman, A. Sugiura, E. N. Arner, A. E. Sewell, M. Z. Madden, R. Okparaugo, E. V. Fallman, K. Gibson-Corley, K. Voss, , J. Rathmell

This study shows that Mecr, a mitochondrial fatty acid synthesis gene, is critical for CD4+ T cell metabolism, function, and survival, with implications for inflammatory diseases and mitochondrial disorders.

bioRxiv · Jul 8, 2024Immunology

Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation

A. Sugiura, K. Beier, C. Chi, D. Heintzman, X. Ye, M. M. Wolf, J.-Y. C. Cephus, H. Hong, C. A. Lyssiotis, D. C. Newcomb, J. Rathmell

This study identifies tissue- and subset-specific roles of SLC38A1 in Th1 cell function during inflammation, showing its importance in EAE and IBD but not lung inflammation.

bioRxiv · Sep 13, 2023 · PreprintImmunology

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

D. Heintzman, J. H. Elasy, C. Chi, X. Ye, E. Krystoviak, W. Khan, L. M. Olson, A. Jones, K. Voss, A. Patterson, A. Sugiura, F. M. Mason, H. Hong, L. E. Bass, K. L. Beier, , J. Rathmell

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

bioRxiv · Nov 14, 2022 · PreprintImmunology