ImmunologybioRxivPreprint
Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation
D. Heintzman, J. H. Elasy, C. Chi…·J. Rathmell
The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.
DOI 10.1101/2022.11.14.516478