D. Horn

Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation

This study identifies CPSF3 as a target of benzoxaboroles in trypanosomatids, showing that BoBs induce sumoylation-dependent degradation of CPSF complex members, leading to reduced mRNA levels.

The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis

This study identifies a non-canonical gluconeogenesis pathway in Trypanosoma brucei by showing sustained metabolic flux despite gene knockouts, suggesting a unique enzyme is involved.

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in T. brucei

The paper identifies ten cAMP Response Proteins (CARPs) in T. brucei, localized to the flagellum, involved in cAMP pathways, with two shown to bind cAMP.

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei

The paper shows that instability of TbAQP2 contributes to drug resistance in Trypanosoma brucei by affecting its folding, oligomerization, and localization.

Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite Trypanosoma brucei

This study uses a genome-scale RNAi screen in Trypanosoma brucei to identify drug efficacy determinants for anti-leishmanial drugs, revealing novel targets and resistance mechanisms.

Proteomic and Genomic Signatures of Repeat-instability in Cancer and Adjacent Normal Tissues

The paper quantifies repeat-instability in cancer and normal tissues using proteomic and genomic data, identifying tumor-specific signatures linked to progression and tumorigenic state.