Author

D. Horn-Ghetko

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. A. Schulman· 1 shared D. A. Perez Berrocal· 1 shared D. T. Vu· 1 shared G. J. van der Heden van Noort· 1 shared J. R. Prabu· 1 shared L. A. Hehl· 1 shared M. P. C. Mulder· 1 shared R. Vollrath· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

B. A. Schulman

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1 paper

Recent·Most cited

BiochemistrybioRxivJun 6, 2023

Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5

L. A. Hehl, D. Horn-Ghetko, J. R. Prabu…·B. A. Schulman

This study uses cryo-EM to reveal the structural mechanism of K48-linked ubiquitin chain formation by the HECT E3 ligase UBR5, showing how it orchestrates ubiquitin transfer through conformational changes.

DOI 10.1038/s41589-023-01414-2

humancryo-EM

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