Author

D. Imhof

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. A. Paul George· 1 shared A. Hemphill· 1 shared A. Ramoji· 1 shared A.-H. M. Mustafa· 1 shared B. F. Schmalohr· 1 shared B. F. Syllwasschy· 1 shared D. Maly· 1 shared E. Fan· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiochemistry

A. A. Paul George

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice.

N. Anghel, P. A. Winzer, D. Imhof, J. Mueller, X. Langa Oliva, J. Rieder, L. K. Barrett, R. S. R. V. Rao Vidadala, W. Huang, R. Choi, M. Hulverson, G. Whitman, S. Arnold, W. Van Voorhis, K. K. Ojo, , A. Hemphill

This study evaluates the effects of 15 bumped kinase inhibitors on zebrafish embryo development and mouse pregnancy, finding limited predictive value of zebrafish tests for pregnancy outcomes.

International Journal of Antimicrobial Agents · Sep 1, 2020Peer-reviewedPathology

Structural insights into the interaction of heme with protein tyrosine kinase JAK2

B. F. Schmalohr, A.-H. M. Mustafa, O. Krämer, D. Imhof

The paper shows heme induces hyperphosphorylation of JAK2 via specific motifs in its kinase domain, suggesting potential for heme-related pharmacological tools in myeloproliferative disorders.

bioRxiv · Aug 13, 2020Biochemistry

Revisiting the interaction of heme with hemopexin: Recommendations for the responsible use of an emerging drug

M. S. Detzel, B. F. Syllwasschy, F. Steinbock, A. Ramoji, M.-T. Hopp, A. A. Paul George, U. Neugebauer, D. Imhof

This study revisits the heme-binding affinity and ratio of hemopexin, finding a lower affinity and potential 2:1 binding ratio, with implications for its therapeutic use in hemolytic disorders.

bioRxiv · Apr 16, 2020 · PreprintBiochemistry