Author

D. J. Evans

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

L. Woodford· 3 shared A. R. Kroken· 2 shared K. Balbirnie-Cumming· 2 shared S. M. J. Fleiszig· 2 shared V. Nieto· 2 shared A. F. Bandak· 1 shared A. Woodman· 1 shared A. Y. Lau· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersMicrobiology

L. Woodford

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome

A. R. Kroken, K. A. Klein, P. S. Mitchell, V. Nieto, E. J. Jedel, D. J. Evans, S. M. J. Fleiszig

This study shows that Pseudomonas aeruginosa suppresses the caspase-4 inflammasome to enable intracellular replication in epithelial cells, highlighting a new role for ExoS in inhibiting host cell death.

bioRxiv · Feb 13, 2023 · PreprintMicrobiology

Pseudomonas aeruginosa can diversify after host cell invasion to establish multiple intracellular niches

N. G. Kumar, V. Nieto, A. R. Kroken, E. Jedel, M. R. Grosser, M. E. Hallsten, M. M. E. Metruccio, T. L. Yahr, D. J. Evans, S. M. J. Fleiszig

This study shows Pseudomonas aeruginosa can persist in vacuoles within host cells despite lacking the T3SS, tolerating antibiotics, and contributing to pathogenesis through intracellular diversification.

bioRxiv · Oct 7, 2022Microbiology

Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events.

K. Bentley, F. G. Alnaji, L. Woodford, S. Jones, A. Woodman, D. J. Evans

The paper investigates how imprecise recombinant viruses evolve through fitness-driven recombination and resolution processes, showing that resolution involves repeated recombination events leading to wild-type genomes.

PLOS Pathogens · Aug 20, 2021Peer-reviewedMicrobiology

First come, first served: Superinfection exclusion in Deformed wing virus is dependent upon sequence identity and not the order of virus acquisition.

O. Gusachenko, L. Woodford, K. Balbirnie-Cumming, D. J. Evans

This study investigates superinfection exclusion in Deformed wing virus (DWV) by analyzing competition between genetically distinct strains and finds that genetic divergence, not acquisition order, determines competitive ability.

bioRxiv · Mar 22, 2021Microbiology

Finding Druggable Sites in Proteins using TACTICS

D. J. Evans, R. A. Yovanno, S. Rahman, D. W. Cao, M. Q. Beckett, M. H. Patel, A. F. Bandak, A. Y. Lau

TACTICS identifies druggable sites in proteins using molecular dynamics data, clustering, random forest, and fragment docking, predicting novel binding sites in SARS-CoV-2 and Yersinia pestis proteins.

bioRxiv · Feb 21, 2021Biophysics

Deformed Wing Virus spillover from honey bees to bumble bees: a reverse genetic study.

O. N. Gusachenko, L. Woodford, K. Balbirnie-Cumming, E. V. Ryabov, D. J. Evans

This study confirms Deformed Wing Virus (DWV) replication in bumble bees using reverse genetics but shows resistance to infection via certain routes.

bioRxiv · Dec 18, 2019Microbiology