S. Jones

S. cerevisiae Cwc15p Tunes the Spliceosome Active Site for Remodeling and Catalysis

This study investigates the role of Cwc15p in S. cerevisiae splicing, finding it stabilizes and facilitates structural transitions of the spliceosome active site, important for splicing under nonoptimal conditions.

Wherefore the magic? The evolutionary role of psilocybin in nature

This study investigates the evolutionary role of psilocybin by testing its effects on Drosophila development and behavior, finding developmental stress and reduced survival but no receptor-specific response.

KIR3DL1 and Tox identify clonally expanded encephalitogenic neuron-specific CD8+ T cells in autoimmune encephalitis

The paper identifies clonally expanded neuron-specific CD8+ T cells in anti-Ri AIE patients using an unbiased approach and shows they express KIR3DL1 and TOX.

Suspension Electrospinning of Decellularized Extracellular Matrix

This paper develops a suspension electrospinning method to create pure decellularized extracellular matrix scaffolds that retain bioactivity, demonstrating its versatility across different decellularization techniques and tissue sources.

Hydrogel-Polyurethane Fiber Composites With Enhanced Microarchitectural Control For Heart Valve Replacement

This paper develops a hydrogel-polyurethane fiber composite for heart valve replacement, showing reduced platelet and bacterial attachment and calcification compared to pericardium, with promising hemodynamic performance.

Distinguishing integrated sub-viral fragments from infectious Rubus yellow net virus in Scottish commercial red raspberry cultivars

The paper identifies partial RYNV genome fragments in raspberry cultivars and shows that these fragments are not infectious, using PCR, sequencing, and grafting experiments.

Rising SARS-CoV-2 Seroprevalence and Patterns of Cross-Variant Antibody Neutralization in UK Domestic Cats

The paper examines SARS-CoV-2 seroprevalence and cross-variant antibody neutralization in UK domestic cats, finding a 3.2% overall seroprevalence with variant-specific responses correlating with human circulation patterns.

A collaborative approach to improving representation in viral genomic surveillance

This paper develops a collaborative genomic surveillance model to improve representation in rural and minority communities, generating over 1,000 SARS-CoV-2 genomes and identifying new variants.

Allelic compatibility in plant immune receptors facilitates engineering of new effector recognition specificities.

This paper demonstrates how allelic compatibility in the Pik NLR pair can be exploited to engineer NLRs with expanded effector recognition specificities without causing constitutive cell death.

Evaluating rotations as a strategy to delay the evolution of insecticide resistance in vectors of human diseases.

This study evaluates insecticide rotation strategies in silico to delay resistance evolution in disease vectors, finding small and unpredictable advantages over sequential deployment.

Conformational flexibility, lipid binding, and regulatory domains in CelTOS

This study identifies key regions and mechanisms of CelTOS pore formation and immunogenicity, with implications for vaccine design against malaria and apicomplexan parasites.

Rapid identification of mosquito species, sex and age by mass spectrometric analysis

This paper uses mass spectrometry to identify mosquito species, sex, and age with high accuracy, offering a faster alternative to traditional methods.

A Multi-proxy assessment of the impact of climate change on Late Holocene (ca 4500-3800 BP) Native American villages of the Georgia coast

This study examines how climate change impacted Native American shell ring villages on Sapelo Island, Georgia, during the Late Archaic Period by analyzing environmental proxies and Bayesian chronological models.

INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury

This study shows that INF2-mediated actin reorganization in neurons protects against ischemic injury by counteracting swelling-induced cell death.

S-acylation stabilizes ligand-induced receptor kinase complex formation during plant pattern-triggered immune signalling.

This study shows S-acylation stabilizes activated receptor kinase complexes at the plasma membrane, enhancing immune signaling in plants.

Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events.

The paper investigates how imprecise recombinant viruses evolve through fitness-driven recombination and resolution processes, showing that resolution involves repeated recombination events leading to wild-type genomes.

Expression of soluble methane monooxygenase in Escherichia coli enables methane conversion

This paper demonstrates the conversion of methane to acetone using engineered Escherichia coli expressing soluble methane monooxygenase.

Experimental infection of specific-pathogen-free domestic lambs with Mycoplasma ovipneumoniae causes asymptomatic colonization of the upper airways that is resistant to antibiotic treatment

This study infects domestic lambs with Mycoplasma ovipneumoniae and finds asymptomatic upper respiratory tract colonization resistant to antibiotics and immune clearance.

Should deep-sequenced amplicons become the new gold-standard for analysing malaria drug clinical trials?

This paper evaluates deep sequenced amplicons (AmpSeq) as a method for molecular correction in malaria drug trials, finding it improves drug failure rate detection compared to current methods.

macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network

This study identifies macroH2A2 as a regulator of chromatin accessibility at enhancers in glioblastoma, showing that inhibiting Menin increases macroH2A2 and represses self-renewal.

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

This study shows that mitochondrial β-oxidation removes oxylipins during bacterial inflammation, with CPT1 playing a key role, and identifies associated genetic upregulation in human sepsis.

Predicting range shifts of African apes under global change scenarios

The paper predicts future distribution shifts of African apes under climate and land-use change scenarios using ensemble forecasting and occurrence data.

Copy when uncertain: Lower light levels result in higher trail pheromone deposition and stronger reliance on pheromone trails in the ant Lasius niger

This study shows that lower light levels in Lasius niger ants lead to increased pheromone trail deposition and greater reliance on pheromone trails when visual information is less reliable.

Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish

This study evaluates the anti-inflammatory effects of synthesised tanshinone and isotanshinone analogues in zebrafish, identifying compounds that accelerate inflammation resolution without affecting host defence.

Dormancy dampens the microbial distance-decay relationship

The paper investigates how microbial dormancy affects biodiversity patterns by analyzing distance-decay relationships in forested ponds using 16S rRNA sequencing.

Juxta-membrane S-acylation of plant receptor-like kinases - fortuitous or functional?

This study investigates whether S-acylation of plant receptor-like kinases adjacent to transmembrane domains is functional or fortuitous, finding it is often chance-based but occasionally evolutionarily selected.

PI31 is an adaptor protein for proteasome transport in axons and required for synaptic development and function

This study identifies PI31 as an adaptor protein linking proteasomes to dynein motors in axons, showing its role in synaptic development and function through regulated transport.

Spatial organization of Clostridium difficile S-layer biogenesis

The paper investigates the spatial organization of S-layer biogenesis in Clostridium difficile, finding that SlpA secretion is delocalized while S-layer formation occurs at sites of cell wall synthesis.

Effects of Fecal Source Input, Environmental Conditions, and Environmental Sources on Enterococci Concentrations in a Coastal Ecosystem

This study examines factors influencing enterococci concentrations in coastal waters, finding that fecal sources, environmental conditions, and reservoirs all contribute to contamination levels.