Author

F. G. Alnaji

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Woodman· 2 shared C. B. Brooke· 2 shared K. Bentley· 2 shared A. Macadam· 1 shared A. Pearson· 1 shared A. te Velthuis· 1 shared C. Brooke· 1 shared D. Evans· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

A. Woodman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Evolutionary BiologyJournal of VirologyPeer-reviewedNov 23, 2021

Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapy

L. Pelz, D. Ruediger, T. Dogra…·U. Reichl

This study investigates the competition between influenza A virus and its defective interfering particles (DIPs) during co-infection, identifying DIPs with superior antiviral efficacy as potential therapeutic candidates.

DOI 10.1128/jvi.01174-21

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologyPLOS PathogensPeer-reviewedAug 20, 2021

Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events.

K. Bentley, F. G. Alnaji, L. Woodford…·D. J. Evans

The paper investigates how imprecise recombinant viruses evolve through fitness-driven recombination and resolution processes, showing that resolution involves repeated recombination events leading to wild-type genomes.

DOI 10.1371/journal.ppat.1009676

long-read sequencingbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivMay 13, 2021

Influenza A virus defective viral genomes are inefficiently packaged into virions relative to wild-type genomic RNAs

F. G. Alnaji, W. K. Reiser, A. te Velthuis, C. B. Brooke

The paper analyzes deletion-containing viral genomes (DelVGs) in influenza A virus infection, revealing packaging inefficiencies and deletion hotspots.

DOI 10.1128/mbio.02959-21

viruswhole-genome sequencing

𝕏 PostBluesky

MicrobiologybioRxivSep 29, 2020

Generated randomly and selected functionally? The nature of enterovirus recombination

F. G. Alnaji, K. Bentley, A. Pearson…·D. Evans

This study investigates the factors influencing recombination in poliovirus, finding that genome function and fitness, rather than sequence identity or structure, determine the identity of recombinant progeny.

DOI 10.3390/v14050916

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologybioRxivPreprintJun 18, 2020

Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

D. Ranoa, R. Holland, F. G. Alnaji…·P. J. Hergenrother

This paper describes a saliva-based SARS-CoV-2 testing method that avoids RNA extraction, achieving a detection limit comparable to nasal swabs and showing good performance with clinical samples.

DOI 10.1101/2020.06.18.159434

humanbulk RNA-seq

𝕏 PostBluesky