Author

D. J. Ham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

M. A. Ruegg· 3 shared S. Lin· 3 shared F. Oliveri· 2 shared K. Chojnowska· 2 shared L. A. Tintignac· 2 shared M. Zavolan· 2 shared N. Mittal· 2 shared A. B. Leuchtmann· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersPhysiology

M. A. Ruegg

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3 papers

Recent·Most cited

Muscle fiber Myc is dispensable for muscle growth and forced expression severely perturbs homeostasis

D. J. Ham, M. Semeraro, B. M. Berger, S. Lin, E. Maino, F. Oliveri, M. A. Ruegg

This study shows that muscle fiber Myc is not required for muscle growth but its overexpression disrupts muscle structure and function.

bioRxiv · Mar 13, 2024 · PreprintPhysiology

Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis

M. S. Kaiser, G. Milan, S. Lin, F. Oliveri, K. Chojnowska, L. A. Tintignac, N. Mittal, C. E. Zimmerli, D. J. Glass, M. Zavolan, D. J. Ham, M. A. Ruegg

The paper reveals that mTORC1 promotes muscle atrophy by enhancing the ubiquitin-proteasome system through dual mechanisms, while also showing that proteome integrity depends on ubiquitination.

bioRxiv · Nov 16, 2021Physiology

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

D. J. Ham, A. Boersch, K. Chojnowska, S. Lin, A. B. Leuchtmann, A. S. Ham, M. Thuerkauf, J. Delezie, R. Furrer, D. Burri, M. Sinnreich, C. Handschin, L. A. Tintignac, M. Zavolan, N. Mittal, M. A. Ruegg

This study shows that calorie restriction and rapamycin have distinct and additive effects on aging skeletal muscle gene expression and function in mice.

bioRxiv · May 28, 2021Physiology