Author

D. J. Knapp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Y. S. Michaels· 2 shared A. Forrow· 1 shared A. Suthananthan· 1 shared B. Bonham-Carter· 1 shared B. Lehnertz· 1 shared C. Zimmerman· 1 shared E. L. Castle· 1 shared F.-M. Cloarec-Ung· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Y. S. Michaels

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification

Y. S. Michaels, M. C. Major, B. Bonham-Carter, J. Zhang, T. Heydari, J. M. Edgar, L. Greenstreet, R. Vilarrasa-Blasi, S. Kim, E. L. Castle, A. Forrow, M. I. Ibanez-Rios, C. Zimmerman, Y. Chung, T. Stach, , P. W. Zandstra

This study uses time-resolved single-cell RNA sequencing to uncover gene expression programs and clonal relationships during human T lineage specification.

bioRxiv · Oct 6, 2023 · PreprintImmunology

Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells

F.-M. Cloarec-Ung, J. Beaulieu, A. Suthananthan, B. Lehnertz, G. Sauvageau, H. M. Sheppard, D. J. Knapp

This study achieves near-perfect on-target gene editing in human hematopoietic stem and progenitor cells with high efficiency and minimal off-target effects.

bioRxiv · May 26, 2023Bioengineering

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression

D. J. Knapp, Y. S. Michaels, M. Jamilly, Q. R. Ferry, H. Barbosa, T. A. Milne, T. A. Fulga

The paper identifies sequence determinants of tRNA promoter and processing activities to engineer a Pol-II promoter for specific guide RNA expression.

bioRxiv · Jun 8, 2018Bioengineering