Author

E. L. Castle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C.-A. Robinson· 3 shared J. A. Corcoran· 3 shared C. Zimmerman· 2 shared J. M. Edgar· 2 shared M. C. Major· 2 shared M. I. Ibanez-Rios· 2 shared M. Kleer· 2 shared P. W. Zandstra· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

C.-A. Robinson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification

Y. S. Michaels, M. C. Major, B. Bonham-Carter, J. Zhang, T. Heydari, J. M. Edgar, L. Greenstreet, R. Vilarrasa-Blasi, S. Kim, E. L. Castle, A. Forrow, M. I. Ibanez-Rios, C. Zimmerman, Y. Chung, T. Stach, , P. W. Zandstra

This study uses time-resolved single-cell RNA sequencing to uncover gene expression programs and clonal relationships during human T lineage specification.

bioRxiv · Oct 6, 2023 · PreprintImmunology

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells

Y. S. Michaels, J. M. Edgar, M. C. Major, E. L. Castle, C. Zimmerman, T. Yin, A. Hagner, C. Lau, M. I. Ibanez-Rios, D. J. H. F. Knapp, P. W. Zandstra

This study identifies DLL4 and VCAM1 as critical factors enhancing T cell progenitor emergence from human pluripotent stem cells during the endothelial-to-hematopoietic transition.

bioRxiv · Nov 26, 2021Bioengineering

Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies

C.-A. Robinson, G. K. Singh, M. Kleer, E. L. Castle, B. Q. Boudreau, J. A. Corcoran

This paper shows KSHV uses the NDP52/CALCOCO2 autophagy receptor to disassemble processing bodies, enhancing inflammation during infection.

bioRxiv · Feb 7, 2021Cell Biology

Human coronaviruses disassemble processing bodies

M. Kleer, R. P. Mulloy, C.-A. Robinson, D. Evseev, M. P. Bui-Marinos, E. L. Castle, A. Banerjee, S. Mubareka, K. Mossman, J. A. Corcoran

This study shows SARS-CoV-2 and related coronaviruses induce processing body disassembly, with SARS-CoV-2's N protein uniquely causing this effect, leading to increased proinflammatory cytokine production.

bioRxiv · Nov 8, 2020Microbiology

Viral manipulation of mechanoresponsive signaling disassembles processing bodies

E. L. Castle, C.-A. Robinson, P. Douglas, K. D. Rinker, J. A. Corcoran

The paper shows that mechanical forces and YAP activation induce PB disassembly through actin rearrangements, using KapB as a tool to uncover this mechanism.

bioRxiv · May 15, 2020Cell Biology