B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1
N. Lee, B.-K. Hong, S. You, R. Kwon, J. Kwon, E. Choi, K.-G. Lee, Y.-M. Kim, Y. Li, J. Kim, Y.-J. Park, Y. Chung, S.-H. Im, L. Sabbagh, C.-S. Cho, W.-U. Kim
This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.
bioRxiv · Jun 28, 2024 · PreprintImmunology