ImmunologybioRxiv
Inflammatory ER Stress Responses Dictate the Immunopathogenic Progression of Systemic Candidiasis
D. Awasthi, S. Chopra, B. A. Cho…·J. R. Cubillos-Ruiz
This study shows that IRE1 hyperactivation in myeloid cells during Candida albicans infection drives renal immunopathology and mortality, and inhibiting IRE1 reduces inflammation and improves survival.
DOI 10.1172/jci167359