K. Miller

Collagen organization and structure in FLBN5-/- mice using label-free microscopy: implications for pelvic organ prolapse

This study uses label-free microscopy to analyze collagen structure in FBLN5-/- mice, finding isotropic collagen and reduced alignment in prolapsed cervix.

Polybacterial intracellular coinfection of epithelial stem cells in periodontitis

This study identifies polybacterial intracellular co-infection in human periodontal epithelial cells, revealing its proinflammatory effects and potential role in chronic diseases.

Human relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice

This study shows that di-n-butyl phthalate exposure reduces ovarian IGF1 system components and disrupts folliculogenesis in mice.

The soluble N-termini of mechanosensitive ion channels MSL8, MSL9, and MSL10 are environmentally sensitive intrinsically disordered regions with distinct biophysical characteristics

This study identifies and characterizes intrinsic disorder in the N-terminal domains of MSL8, MSL9, and MSL10, showing distinct biophysical properties and environmental responsiveness.

In vitro experiments and kinetic models of pollen hydration show that MSL8 is not a simple tension-gated osmoregulator

The paper tests if MSL8 functions as a tension-gated osmoregulator in pollen hydration using experiments and models, finding it instead strengthens the cell wall.

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

Interactions between a mechanosensitive channel and cell wall integrity signaling influence pollen germination in Arabidopsis thaliana

This study investigates how mechanosensitive channels and cell wall integrity signaling interact during pollen germination in Arabidopsis thaliana, revealing their roles in callose deposition and cell integrity.

A new Spirodela polyrhiza genome and proteome reveal a conserved chromosomal structure with high abundances of proteins favoring energy production

This paper presents a new genome and proteome of Spirodela polyrhiza, revealing conserved chromosomal structure and high abundance of energy-related proteins.

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

This study identifies how EGFR differentiates signaling outputs from EGF and TGF- through conformational changes in its extracellular domain.

Ecological and evolutionary patterns in the enigmatic protist genus Percolomonas (Heterolobosea; Discoba) from diverse habitats

The paper analyzes 18S rRNA gene sequences from seven Percolomonas cosmopolitus-like strains from diverse salinities, revealing cryptic species and ecological specialization.

MUTE Directly Orchestrates Cell State Switch and the Single Symmetric Division to Create Stomata

The paper identifies MUTE's role in orchestrating cell state switch and single symmetric division during stomatal differentiation by regulating gene expression and forming an Incoherent Type 1 Feed-Forward Loop.

Antimalarial pantothenamide metabolites target acetyl-CoA synthesis in Plasmodium falciparum

Pantothenamides form antimetabolites that interfere with acetyl-CoA metabolism in the human malaria parasite Plasmodium falciparum.

Habits without Values

This paper develops a computational model of habits based on value-free mechanisms, showing it accounts for habit-related behaviors like insensitivity to outcome devaluation and perseveration.