Extracellular histones trigger disseminated intravascular coagulation by lytic cell death
C. Wu, Y. Zhang, L. Li, A. Pandeya, G. Zhang, J. Cui, D. Kirchhofer, J. P. Wood, S. S. Smyth, Y. Wei, Z. Li
The paper shows extracellular histones cause disseminated intravascular coagulation (DIC) via tissue factor-dependent lytic cell death, independent of inflammasome or TLR pathways.
bioRxiv · Jun 11, 2020 · PreprintImmunology