D. L. Adelson

Validating the Target Functions and Synergistic Multi-Target, Multi-Pathway Action Mode of Compound Kushen Injection Using CRISPR/CAS

This study validates the multi-target, multi-pathway action of Compound Kushen Injection by knocking out key genes in cell lines and observing changes in CKI efficacy.

Jumping between Turtles, Fishes, and a Frog: The Unexpected Horizontal Transfer of a DNA Transposon

The paper identifies a recent horizontal transfer of the hAT-6 DNA transposon between turtles, fishes, and a frog, highlighting its functional transposition activity despite turtles' low genomic evolutionary rate.

Horizontal transposon transfer and its implications for the ancestral ecology of hydrophiine snakes

The paper examines horizontal transposon transfer in Hydrophiinae snakes to infer their ancestral ecological route from Asia to Australia.

Genome stability is in the eye of the beholder: recent retrotransposon activity varies significantly across avian diversity

This study examines CR1 retrotransposon activity across avian species, finding significant variation in TE expansion rates among orders and clades, challenging the notion of low TE activity in birds.

New environment, new invaders - repeated horizontal transfer of LINEs to sea snakes

The paper identifies repeated horizontal transfer of LINE retrotransposons in marine sea snakes, suggesting marine environments facilitate transposon transfer and genomic novelty.

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection with Transcriptome Analysis

This study uses transcriptome analysis to investigate how two herbal extracts in Compound Kushen Injection interact, showing Kushen drives cytotoxicity and Baituling enhances it while activating immune pathways.

A new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle

This paper introduces a transcriptome analysis workflow to study drug-drug interactions, using Compound Kushen Injection and chemotherapy drugs as a proof of principle, identifying MYD88 as a key regulator.

The Effect of Compound Kushen Injection on Cancer Cells: Integrated Identification of Candidate Molecular Mechanisms.

This study identifies candidate molecular mechanisms of Compound Kushen Injection by analyzing transcriptome changes in cancer cells and linking them to gene expression and pathway alterations.

Effect of Compound Kushen Injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain and breast cancer cell lines

This study evaluates the effects of Compound Kushen Injection and its components on cancer cell migration and invasion in multiple cell lines, finding reduced motility and invasiveness.

Fractional Deletion Of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical For Its Perturbation Of The Cell Cycle.

This study identifies critical compounds in Compound Kushen Injection (CKI) that modulate cell cycle and apoptosis through cytokine signaling pathways.

Cell Cycle, Energy Metabolism and DNA Repair Pathways in Cancer Cells are Suppressed by Compound Kushen Injection.

This study shows that Compound Kushen Injection suppresses cell cycle, DNA repair, and energy metabolism in cancer cells, while its major component oxymatrine has limited effects.

Divergent genome evolution caused by regional variation in DNA gain and loss between human and mouse

This study identifies regional variation in DNA gain and loss between human and mouse genomes, linking these events to chromatin states and biological processes.

Similar evolutionary trajectories for retrotransposon accumulation in mammals

The paper investigates retrotransposon accumulation patterns across mammalian genomes, finding similar evolutionary trajectories despite differences in retrotransposon types.