Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated Lipogenesis
S. M. Johnson, H. Bao, C. McMahon, Y. Chen, S. Burr, A. Anderson, K. Madeyski-Bengtson, D. Linden, X. Han, J. Liu
This study defines the physiological role of wild-type PNPLA3 in maintaining hepatic VLDL-TG secretion and shows that the I148M variant impairs this function during lipogenic conditions.
bioRxiv · Aug 30, 2023 · PreprintPhysiology