Intestinal stem cell aging at single-cell resolution: functional perturbations alter cell developmental trajectory reversed by gerotherapeutics
J. Choi, M. Houston, R. Wang, K. Ye, W. Li, X. Zhang, D. M. Huffman, L. H. Augenlicht
This study uses single-cell RNA sequencing to show that aging impairs intestinal stem cell maturation, which is reversed by metformin and rapamycin.
bioRxiv · Aug 31, 2022 · PreprintCell Biology