Cancer BiologybioRxivPreprint
Mechanism-guided quantification of LINE-1 reveals p53 regulation of both retrotransposition and transcription
A. Solovyov, J. M. Behr, D. Hoyos…·B. D. Greenbaum
This study quantifies LINE-1 retrotransposition and expression in cancer, showing TP53 mutations enable retrotransposition by disinhibiting L1 expression and enabling reintegration.
DOI 10.1101/2023.05.11.539471