Author

A. Solovyov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:whole-genome sequencing· 2 Approach:benchmark study· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. D. Greenbaum· 3 shared N. Vabret· 3 shared D. Hoyos· 2 shared D. T. Ting· 2 shared N. Bhardwaj· 2 shared A. D. Gioacchino· 1 shared A. Karacay· 1 shared A. Komarova· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

B. D. Greenbaum

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

S. Sun, J. Hong, E. You, K. M. Tsanov, J. Chacon-Barahona, A. D. Gioacchino, D. Hoyos, H. Li, H. Jiang, H. Ly, S. A. Marhon, R. Murali, P. Chanda, A. Karacay, N. Vabret, , B. D. Greenbaum

This study shows pancreatic tumors co-evolve with retrotransposons to modulate immune responses by regulating viral mimicry through SINEs and L1 retrotransposition.

bioRxiv · May 19, 2023 · PreprintCancer Biology

Mechanism-guided quantification of LINE-1 reveals p53 regulation of both retrotransposition and transcription

A. Solovyov, J. M. Behr, D. Hoyos, E. M. Banks, A. W. Drong, J. Z. Zhong, E. Garcia-Rivera, W. McKerrow, C. Chu, D. M. Zaller, M. Fromer, B. D. Greenbaum

This study quantifies LINE-1 retrotransposition and expression in cancer, showing TP53 mutations enable retrotransposition by disinhibiting L1 expression and enabling reintegration.

bioRxiv · May 11, 2023 · PreprintCancer Biology

Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV

N. Vabret, V. Najburg, A. Solovyov, P. Sulc, S. Balan, G. Beauclair, M. Chazal, H. Varet, R. Legendre, O. Sismeiro, R. Sanchez David, C. McClain, R. Gopal, L. Chauveau, O. Schwartz, , A. Komarova

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.

bioRxiv · Sep 18, 2019Immunology

Global Cancer Transcriptome Quantifies Repeat Element Polarization Between Immunotherapy Responsive and T cell Suppressive Classes

A. Solovyov, N. Vabret, K. S. Arora, A. Snyder, S. A. Funt, D. F. Bajorin, J. E. Rosenberg, N. Bhardwaj, D. T. Ting, B. D. Greenbaum

The paper quantifies repeat element polarization in cancer transcriptomes to identify biomarkers for immunotherapy response and tumor microenvironment immunosuppression.

bioRxiv · Jun 4, 2017Cancer Biology