A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices.
H. Paish, L. Reed, H. Brown, M. Bryan, O. Govaere, J. Leslie, B. Barksby, J. French, S. White, D. Manas, S. Robinson, G. Spoletini, C. Griffiths, D. Mann, L. Borthwick, , F. Oakley
This paper develops a bioreactor system that extends the viability of precision-cut liver slices (PCLS) to 6 days under normoxic conditions and demonstrates its use in modeling fibrogenesis and testing anti-fibrotic drugs.
bioRxiv · May 25, 2018Cell Biology