D. Mann

Structural plasticity of Atg18 oligomers: organization of assembled tubes and scaffolds at the isolation membrane

This study determines the cryo-EM structures of Atg18 oligomers and their interactions with lipid membranes, revealing their role in coordinating autophagy machinery components.

Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome

This study uses single-particle cryo-EM to determine the structure of a native α-carboxysome from a marine cyanobacterium, revealing its shell architecture and internal enzyme organization.

Improving Lab Culture Through Self-Assessment: A Case Study

The paper describes a self-assessment process to improve lab culture through surveys and group discussions, resulting in a 12% increase in member satisfaction.

The cryo-EM structure of the bacterial type I DNA segregation ATPase filament reveals its conformational plasticity upon DNA binding.

This study reports the cryo-EM structure of a bacterial ParA filament bound to DNA, revealing conformational changes and nucleotide-dependent filament formation.

PspA adopts an ESCRT-III-like fold and remodels bacterial membranes

This study presents the cryo-EM structure of PspA and shows its ability to remodel bacterial membranes through ESCRT-III-like mechanisms.

Structure and lipid dynamics in the A. baumannii maintenance of lipid asymmetry (MLA) inner membrane complex

This study reports cryo-EM structures of the A. baumannii MLA complex in different states and proposes a molecular mechanism for lipid transport.

Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy

This study uses FLIM and a fluorescent probe to visualize G4 structures in live cells and assesses their stability and resolution by small molecule interactions.

Augmenting biologging with supervised machine learning to study in situ behavior of the medusa Chrysaora fuscescens

The paper uses biologging and supervised machine learning to study in situ behavior of jellyfish, identifying tag data corruption and classifying behaviors for long-term activity analysis.

A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices.

This paper develops a bioreactor system that extends the viability of precision-cut liver slices (PCLS) to 6 days under normoxic conditions and demonstrates its use in modeling fibrogenesis and testing anti-fibrotic drugs.