Author

L. Borthwick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:rat· 1

Frequent Co-Authors

F. Oakley· 2 shared H. Paish· 2 shared J. Leslie· 2 shared J. Mann· 2 shared A. Santos-Ledo· 1 shared A. Watson· 1 shared B. Barksby· 1 shared C. Griffiths· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

F. Oakley

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2 papers

Recent·Most cited

mTORC1-Plin3 pathway is essential to activate lipophagy and protects against hepatosteatosis.

M. Garcia-Macia, A. Santos-Ledo, J. Leslie, H. Paish, A. Watson, L. Borthwick, J. Mann, F. Oakley, V. I. Korolchuk, D. A. Mann

This study identifies the mTORC1-Plin3 pathway as essential for lipophagy, which protects against hepatosteatosis by promoting lipid droplet degradation.

bioRxiv · Oct 21, 2019Cell Biology

A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices.

H. Paish, L. Reed, H. Brown, M. Bryan, O. Govaere, J. Leslie, B. Barksby, J. French, S. White, D. Manas, S. Robinson, G. Spoletini, C. Griffiths, D. Mann, L. Borthwick, , F. Oakley

This paper develops a bioreactor system that extends the viability of precision-cut liver slices (PCLS) to 6 days under normoxic conditions and demonstrates its use in modeling fibrogenesis and testing anti-fibrotic drugs.

bioRxiv · May 25, 2018Cell Biology