Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin
S. Xu, D. MO, F. Z. Rizvi, J. Rosa, J. Ruiz, S. Tan, R. K. Tweten, J. M. Leong, W. Adams
This study shows that pneumolysin from S. pneumoniae disrupts E-cadherin localization through PLY-dependent and -independent mechanisms, but maximal bacterial translocation requires PLY-dependent neutrophil recruitment.
bioRxiv · Jun 1, 2023 · PreprintMicrobiology