MicrobiologybioRxivPreprint
Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin
S. Xu, D. MO, F. Z. Rizvi…·W. Adams
This study shows that pneumolysin from S. pneumoniae disrupts E-cadherin localization through PLY-dependent and -independent mechanisms, but maximal bacterial translocation requires PLY-dependent neutrophil recruitment.
DOI 10.1101/2023.06.01.543286