Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function
M. K. Culley, M. Mehta, J. Zhao, D. Perk, Y. Y. Tai, Y. Tang, S. Shiva, M. Rabinovitch, M. Gu, T. Bertero, S. Y. Chan
This study shows that frataxin deficiency in endothelial cells causes mitochondrial respiration defects and vasoconstriction, contributing to pulmonary hypertension.
bioRxiv · Aug 22, 2022Cell Biology