M. Gu

Gradual labeling with fluorogenic probes for MINFLUX nanoscopy of densely packed structures

This paper introduces GLF-MINFLUX, a method for nanoscale imaging of densely packed structures, achieving improved localization precision and faster acquisition.

Sarbecovirus RBD indels and specific residues dictating ACE2 multi-species adaptiveness

This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.

Rice OsHAK18 mediates shoot-to-root circulation of potassium and sodium and source-to-sink transport of soluble sugar

Rice OsHAK18 mediates shoot-to-root potassium and sodium circulation and source-to-sink sugar transport, improving potassium use efficiency and grain yield.

Brain Organoid Computing for Artificial Intelligence

The paper develops Brainoware, a living AI hardware using 3D brain organoids to compute nonlinear equations and demonstrate learning capabilities.

Engineering human spinal microphysiological systems to model opioid-induced tolerance

This paper develops human spinal microphysiological systems to model opioid-induced tolerance and hyperalgesia, showing altered neural activity and receptor downregulation with prolonged opioid exposure.

Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition

The paper identifies host range determinants of ACE2-using MERS-related coronaviruses by analyzing receptor recognition across mammals.

TMEM100, a Lung-Specific Endothelium Gene

This study identifies Tmem100 as a lung-specific endothelial gene through single-cell RNA-sequencing analysis.

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

This study shows that frataxin deficiency in endothelial cells causes mitochondrial respiration defects and vasoconstriction, contributing to pulmonary hypertension.

Real-time feeding behavior monitoring by electrical penetration graph rapidly reveals host plant susceptibility to crapemyrtle bark scale (Hemiptera: Eriococcidae)

This paper develops an EPG-based method to rapidly assess plant susceptibility to crapemyrtle bark scale by analyzing real-time feeding behavior parameters.

Green Lacewing Chrysoperla rufilabris (Neuroptera: Chrysopidae) is a potential biological agent for controlling crapemyrtle bark scale (Hemiptera: Eriococcidae)

This study confirms that larval green lacewing Chrysoperla rufilabris preys on crapemyrtle bark scale at different life stages and shows its potential as a biological control agent.

Antiviral DExD/H-box helicase 60 selectively inhibits translation from type II internal ribosome entry sites

This study shows that DDX60 selectively inhibits translation from type II viral IRESs, reducing replication of EMCV and FMDV but not type I IRES viruses.

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

Understanding immune-driven brain aging by human brain organoid microphysiological analysis platform

This study develops a human brain organoid microphysiological platform to model immune-driven brain aging by perfusing aged monocytes and observing their effects on organoid tissues.

Multi-Functionalized Self-Bonding MXene for Minimal-invasive Jet-injected Neural Interface and Tissue Healing

The paper develops a minimal-invasive neural interface using MXene nanosheets to promote nerve regeneration and electrophysiology recording in mice.

One dose of COVID-19 nanoparticle vaccine REVC-128 provides protection against SARS-CoV-2 challenge at two weeks post immunization

SNHG16 promotes cell proliferation and inhibits cell apoptosis via regulation of the miR-1303p/STARD9 axis in renal cell carcinoma

This study identifies SNHG16 as a promoter of renal cell carcinoma proliferation and inhibitor of apoptosis through the miR-1301-3p/STARD9 axis.

Endogenous Retroviral Elements Generate Pathologic Neutrophils and Elastase Rich Exosomes in Pulmonary Arterial Hypertension

The paper shows that endogenous retroviruses contribute to neutrophil dysfunction and exosome-mediated pulmonary arterial hypertension.

Global profiling of the crotonylome in Small Cell Lung Cancer

The paper profiles the crotonylome in Small Cell Lung Cancer tissues compared to normal lung tissues, identifying unique protein crotonylation patterns in cancer-related pathways.

KAT7 is a therapeutic vulnerability of MLL-rearranged acute myeloid leukemia

This study identifies KAT7 as a critical therapeutic target in MLL-rearranged AML by showing its role in maintaining acetylation marks and supporting cell proliferation.

Biochar effect - mediated ammonium transporter genes and GDH may be the core of improvement nitrogen assimilation in cotton seedling

The paper investigates how biochar affects nitrogen assimilation in cotton seedlings by analyzing gene expression and enzyme activity under different urea and biochar conditions.

microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis

The paper identifies microRNA-dependent regulation of biomechanical genes that maintain tissue stiffness homeostasis through cytoskeletal and extracellular matrix control.

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

This study identifies LEM2 and CHMP7 as conserved factors that recruit ESCRT-III proteins to the nuclear envelope during closure in fission yeast and human cells.