M. Mehta

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

This study shows that frataxin deficiency in endothelial cells causes mitochondrial respiration defects and vasoconstriction, contributing to pulmonary hypertension.

Understanding spatiotemporal effects of food supplementation on host-parasite interactions using community-based science

This study examines how food supplementation affects eastern bluebirds and their nest parasites across the eastern U.S., finding increased fledgling success but inconsistent parasite defense effects.

Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures in immune cells and podocytes

This study uses urine single cell RNA-sequencing to identify inflammatory signatures in immune cells and podocytes in FSGS, suggesting potential for non-invasive diagnosis and biomarker discovery.

Robust lysosomal rewiring in Mtb infected macrophages mediated by Mtb lipids restricts the intracellular bacterial survival

The paper shows that Mtb lipids induce lysosomal rewiring in infected macrophages, enhancing host defense and restricting bacterial survival.

Single-cell profiling of tumor-reactive CD4+ T-cells reveals unexpected transcriptomic diversity

The paper uses single-cell RNA sequencing to reveal diverse transcriptomic patterns in CD4+ T cells responding to tumors, highlighting differences from virus responses and potential implications for immunotherapy.

Redox-Dependent Condensation Of the Mycobacterial Nucleoid By WhiB4

This paper identifies WhiB4 as a redox-dependent nucleoid condensing protein in Mtb that links oxidative stress response with genome organization and gene expression.