S. Y. Chan

This study shows that frataxin deficiency in endothelial cells causes mitochondrial respiration defects and vasoconstriction, contributing to pulmonary hypertension.

This study uses multi-omic approaches to analyze CIC's functional networks, identifying novel interactions and revealing its role in mitotic fidelity and transcriptional splicing.

This study shows EBP50 downregulation promotes EndMT in pulmonary hypertension by increasing Snail, Zeb1, and Slug expression, and mesenchymal markers, while reducing cell proliferation and barrier function.

This study isolates and characterizes testicular extracellular vesicles, identifies their cargo, and shows their role in inter-compartmental communication during spermatogenesis.

This study shows mechanical forces rewire glutamine metabolism to promote microtubule glutamylation, affecting cell mechanics and mechanodependent functions.