Author

D. Prakaash

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Approach:mechanistic / dynamical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. C. Kalli· 3 shared O. Acuto· 3 shared G. P. Cook· 2 shared A. Cohnen· 1 shared A.-L. Lanz· 1 shared D. Cipria· 1 shared D. Cole· 1 shared D. Galgano· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiophysics

A. C. Kalli

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3 papers

Recent·Most cited

Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase Lck

D. Prakaash, G. P. Cook, O. Acuto, A. C. Kalli

This study uses molecular dynamics simulations to show that Lck interacts with PIP lipids in both open and closed conformations, suggesting lipid interactions regulate its conformation and T cell signaling.

bioRxiv · May 10, 2022 · PreprintBiophysics

Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region

D. Prakaash, G. P. Cook, O. Acuto, A. C. Kalli

This study uses multi-scale simulations to investigate TCR-CD3 conformational dynamics, cytoplasmic tail arrangement, and lipid interactions, revealing their role in T cell activation.

PLOS Computational Biology · Jul 19, 2021Peer-reviewedBiophysics

Allosteric activation of T-cell antigen receptor signalling by quaternary structure relaxation

A.-L. Lanz, G. Masi, N. Porciello, A. Cohnen, D. Cipria, D. Prakaash, S. Balint, R. Raggiaschi, D. Galgano, D. Cole, M. Lepore, O. Dushek, M. Dustin, M. Sansom, A. C. Kalli, O. Acuto

This study identifies mutations that enhance TCR-CD3 signalling by loosening TCR{beta} and CD3{zeta} interactions, showing pMHC binding can induce allosteric changes and initiate signal propagation.

bioRxiv · Dec 2, 2020Immunology