O. Acuto

Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase Lck

This study uses molecular dynamics simulations to show that Lck interacts with PIP lipids in both open and closed conformations, suggesting lipid interactions regulate its conformation and T cell signaling.

A role of Lck annular lipids in the steady upkeep of active Lck in T cells

The paper investigates how annular lipids affect Lck kinase activity in T cells by examining the balance between autophosphorylation and dephosphorylation by CD45.

Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region

This study uses multi-scale simulations to investigate TCR-CD3 conformational dynamics, cytoplasmic tail arrangement, and lipid interactions, revealing their role in T cell activation.

Allosteric activation of T-cell antigen receptor signalling by quaternary structure relaxation

This study identifies mutations that enhance TCR-CD3 signalling by loosening TCR{beta} and CD3{zeta} interactions, showing pMHC binding can induce allosteric changes and initiate signal propagation.

The full model of the pMHC-TCR-CD3 complex: a structural and kinetics characterization

The paper presents the first full model of the pMHC-TCR-CD3 complex, revealing conformational changes and signal propagation mechanisms through molecular dynamics simulations.

Activation of Src-family kinases orchestrate secretion of flaviviruses by targeting mature progeny virions to secretory autophagosomes

This study identifies Lyn-dependent secretory autophagosomes as a novel pathway for flavivirus secretion, enabling evasion of antibodies and tissue tropism.

Phosphoproteomics of CD2 signaling reveals an AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells