Author

D. Cole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 1 Ecology· 1 Immunology· 1 Microbiology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Approach:microscopy & imaging analysis· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Assay:DNA methylation· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

P. Kukura· 3 shared A. Fineberg· 2 shared G. Young· 2 shared J. Andrecka· 2 shared J. R. Sellers· 2 shared N. Billington· 2 shared Y. Takagi· 2 shared A. A. Chen· 1 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

P. Kukura

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Author profile →

8 papers

Recent·Most cited

Tuning the stability of DNA tetrahedra with base-stacking interactions

J. A. Punnoose, D. Cole, T. Melfi, V. Morya, B. R. Madhanagopal, A. A. Chen, S. A. Vangaveti, A. R. Chandrasekaran, K. Halvorsen

This study investigates how base-stacking interactions affect the stability of DNA tetrahedra by testing 16 designs, finding that altering a single base stack can change melting temperatures by up to 10°C.

bioRxiv · Jun 10, 2024 · PreprintBioengineering

Deepening biomedical research training: Community-Building Wellness Workshops for Post-Baccalaureate Research Education Program (PREP) Trainees

D. Cole, A. S. Eneim, C. J. White, C. R. Eddings, M. Q. Beckett, V. Clark, J. Jeffery, V. K. Wimalasena, A. Figueroa, J. J. Rosado-Franco, R. Alhariri, B. H. Powell, P. W. Washington, L. N. Christensen, K. L. Wilson, J. M. Kavran

This paper describes a wellness program for PREP trainees that improved their resilience and skills through community-building workshops and peer mentorship.

bioRxiv · Mar 10, 2024 · PreprintScientific Communication & Education

Myosin-5 varies its steps along the irregular F-actin track

A. Fineberg, Y. Takagi, K. Thirumurugan, J. Andrecka, N. Billington, G. Young, D. Cole, S. A. Burgess, A. P. Curd, J. A. Hammer, J. R. Sellers, P. Kukura, P. J. Knight

This study reveals that myosin-5 takes variable step lengths along F-actin tracks, adapting to angular disorder in the track structure.

bioRxiv · Jul 16, 2023Biophysics

Allosteric activation of T-cell antigen receptor signalling by quaternary structure relaxation

A.-L. Lanz, G. Masi, N. Porciello, A. Cohnen, D. Cipria, D. Prakaash, S. Balint, R. Raggiaschi, D. Galgano, D. Cole, M. Lepore, O. Dushek, M. Dustin, M. Sansom, A. C. Kalli, O. Acuto

This study identifies mutations that enhance TCR-CD3 signalling by loosening TCR{beta} and CD3{zeta} interactions, showing pMHC binding can induce allosteric changes and initiate signal propagation.

bioRxiv · Dec 2, 2020Immunology

The fiber knob protein of human adenovirus type 49 mediates highly efficient and promiscuous infection of cancer cell lines using a novel cell entry mechanism

A. T. Baker, G. L. Marlow, J. Davies, E. Moses, R. M. Mundy, D. Cole, P. J. Rizkallah, A. L. Parker

This paper investigates HAdV-D49's novel cell entry mechanism, showing its pseudotyped vector efficiently infects cancer cell lines lacking known adenovirus receptors.

bioRxiv · Jul 20, 2020Microbiology

Size- and stage-dependence in cause-specific mortality of migratory brown trout

C. R. Nater, Y. Vindenes, P. Aass, D. Cole, O. Langangen, J. Moe, A. Rustadbakken, D. Turek, L. A. Vollestad, T. Ergon

The paper estimates cause-specific mortality in brown trout, showing harvest mortality peaks at intermediate sizes and background mortality varies with size and spawning location.

bioRxiv · Jan 28, 2020Ecology

Complementary studies of lipid membrane dynamics using iSCAT and super-resolved Fluorescence Correlation Spectroscopy

F. Reina, S. Galiani, D. Shrestha, E. Sezgin, G. de Wit, D. Cole, B. C. Lagerholm, P. Kukura, C. Eggeling

This paper compares STED-FCS and iSCAT techniques for measuring lipid diffusion on SLBs using hybrid fluorescent-gold nanoparticle tags, finding significant differences in diffusion coefficients.

bioRxiv · Apr 13, 2018Biophysics

Quantitative mass imaging of single molecules in solution

G. Young, N. Hundt, D. Cole, A. Fineberg, J. Andrecka, A. Tyler, A. Olerinyova, A. Ansari, E. G. Marklund, M. P. Collier, S. A. Chandler, O. Tkachenko, J. Allen, M. Crispin, N. Billington, , P. Kukura

This paper introduces a method to mass-image single biomolecules in solution with high precision and resolution, enabling the study of molecular interactions and assemblies.

bioRxiv · Dec 6, 2017Biophysics