M. Dustin

Sympathetic neuron-derived NPY protects from obesity by sustaining the mural progenitors of thermogenic adipocytes.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells

This study compares cytokine production kinetics in TCR-T cells and CAR-T cells with and without co-stimulation, finding that 2nd-generation CAR-T cells sustain cytokine production without co-stimulation.

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

This study shows LAT1 is critical for T cell activation in rheumatoid arthritis and identifies it as a therapeutic target, with a LAT1 inhibitor effective in mouse models.

Dynamic mitochondrial transcription and translation in B cells control germinal centre entry and lymphomagenesis

This study shows that mitochondrial transcription and translation in B cells are critical for germinal centre entry and lymphomagenesis, with TFAM playing a key role.

Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse through distinct adaptors

The paper shows clathrin mediates TCR internalization and vesicular release at the immunological synapse through distinct adaptors HRS/STAM2 and EPN1.

3D single molecule localization microscopy reveals the topography of the immunological synapse at isotropic precision below 15 nm

This study uses 3D-SMLM to measure the cleft size in immunological synapses between T-cells and lipid bilayers, finding distances of 18-31 nm.

Coordination of KIF3A and KIF13A regulates leading edge localization of MT1-MMP in cancer cells

The paper identifies KIF3A and KIF13A coordination in transporting MT1-MMP vesicles to the leading edge, inhibiting cancer cell invasion when knocked down.

A Simple Ultrafast Multicolor Immunolabelling and Clearing Approach for Whole-Organ and Large Tissue 3D Imaging

The paper introduces SUMIC, a fast and simple method for whole-organ and large tissue 3D imaging, revealing age-related expansion of lymphatic vessels in endocrine tissues.

Allosteric activation of T-cell antigen receptor signalling by quaternary structure relaxation

This study identifies mutations that enhance TCR-CD3 signalling by loosening TCR{beta} and CD3{zeta} interactions, showing pMHC binding can induce allosteric changes and initiate signal propagation.

The discriminatory power of the T cell receptor

This study measures TCR discriminatory power against pMHC antigens and finds it is imperfect, with T cells responding to low-affinity self pMHC with KD ~1 mM.

T cells exhibit unexpectedly low discriminatory power and can respond to ultra-low affinity peptide-MHC ligands

The paper measures ultra-low TCR/pMHC affinities and finds T cells have low discriminatory power, requiring large affinity differences to trigger responses.

Intercellular telomere transfer extends T cell lifespan

The paper shows T cells extend telomeres by acquiring telomere vesicles from APCs, independent of telomerase, thereby increasing their lifespan.

Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells

This study identifies immune cell states in pancreatic cancer, showing regulatory T-cells and dysfunctional CD8+ T-cells contribute to a suppressive microenvironment, suggesting new therapeutic targets.

Regulated unbinding of ZAP70 at the T cell receptor by kinetic avidity

The paper shows that ZAP70 unbinding from TCR is regulated by kinetic avidity, allowing both signal fidelity and reversibility in T cell responses.

IL-15 re-programming compensates for NK cell mitochondrial dysfunction in HIV-1 infection

This study shows that IL-15 treatment improves NK cell function in HIV-1 infection by enhancing mTORC1 activity and compensating for mitochondrial dysfunction.

Cytoskeletal tension actively sustains the migratory T cell synaptic contact

This study identifies a mechanical mechanism involving cytoskeletal tension that sustains T cell-APC synaptic contact symmetry and stability.